Comparing the sedative property of two commonly used drugs in surgical patients who are otherwise healthy

A COMPARATIVE STUDY OF KETAMINE PROPOFOL AND KETAMINE DEXMEDETOMIDINE FOR IV SEDATION IN SHORT PROCEDURES A RANDOMIZED CONTROL STUDY - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080593

Enrollment

140

Registered

2025-02-14

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Inj.Dexmedetomidine inj.ketamine: Inj.Dexmedetomidine intravenous administration 0.5microgram/kg single dose Inj.ketamine 1mg/kg intravenous route single dose Control Intervention1: In

Eligibility

Inclusion criteria

Inclusion criteria: American soceity of anaesthesiologist grade 1&2 patients, weight 40-80kgs, patients undergoing elective short duration daycare surgical procedures

Exclusion criteria

Exclusion criteria: Patient refusal, patients allergic to any drugs, patients with any uncontrolled systemic illnesses American soceity of anaesthesiologist grade 3&4 ,

Design outcomes

Primary

Measure	Time frame
Time to first rescue ketamine bolus dose, total number of rescue boluses, sedation score, recovery time after last rescue bolusTimepoint: Time of 2nd dose of ketamine after 1st dose of ketamine, total number of injection ketamine , sedation score baseline, 10minutes, 20minutes, 30minutes after propofol or dexmedetomidine injection in both groups, recovery time and sedation score postoperatively 10minutes, 20minutes, 30minutes	—

Measure

Time frame

Time to first rescue ketamine bolus dose, total number of rescue boluses, sedation score, recovery time after last rescue bolusTimepoint: Time of 2nd dose of ketamine after 1st dose of ketamine, total number of injection ketamine , sedation score baseline, 10minutes, 20minutes, 30minutes after propofol or dexmedetomidine injection in both groups, recovery time and sedation score postoperatively 10minutes, 20minutes, 30minutes

—

Secondary

Measure	Time frame
Pulse rate, systolic blood pressure, diastolic blood pressure, oxygen saturation, vomiting,Timepoint: Pulse rate , systolic blood pressure, diastolic blood pressure, , oxygen saturation baseline,preinduction, 5,10,20,30,40 minutes intraoperatively, 5,10,20,30 minutes , 2hour postoperatively	—

Countries

India

Contacts

Public ContactB.SUNDARI

TRICHY SRM MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTRE

dr.b.sundari@gmail.com9677596700

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026