A Study Comparing Two Treatment Methods for Women with Low Ovarian Reserve Who Struggle to Respond to IVF, to See Which One Works Better

Comparing IVF Outcomes of Progestin Primed Ovarian stimulation(PPOS) with Ultrashort flare(USF)GnRH Agonist in Expected Poor responders(POSEIDON 3,4)-A Multicentric Randomised controlled Trail - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080584

Enrollment

220

Registered

2025-02-14

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O090- Supervision of pregnancy with history of infertility

Interventions

Intervention1: Progestin primed ovarian stimulation (PPOS): T.Medroxy progesterone acetate 10 mg once daily orally along with gonadotrophins from D2 of menstrual cycle (maximum dose 375 IU of HP HMG

Eligibility

Inclusion criteria

Inclusion criteria: Expected Poor responders as defined by POSEIDON criteria (Groups 3-4). Freeze all cycles

Exclusion criteria

Exclusion criteria: Women with any current or past diseases affecting ovaries Hypogonadotrophic hypogonadism Premature ovarian insufficiency

Design outcomes

Primary

Measure	Time frame
Oocyte Retrieval Rate,Maturation rate ,Fertilization rate, ,blastulation rate .Timepoint: Till 1 year	—

Secondary

Measure	Time frame
days of stimulation ,Total gonadotropin dosage ,cycle cancellation rate , Follicular output rate(FORT) ,Follicle to oocyte index(FOI ),Implantation rate (IR),Biochemical pregnancy(BPR),Clinical pregnancy rate (CPR),Miscarriage rate (MR),Multiple pregnancy rate (MPR) ,Utilization rateTimepoint: From time of recruitment till three to four months	—

Countries

India

Contacts

Public ContactDrKrishna chaitanya

OASIS Fertility hospital -unit of Sadguru healthcare services pvt.Ltd, HYDERABAD

quality@oasisindia.in8008812999

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026