Health Condition 1: M321- Systemic lupus erythematosus withorgan or system involvement
Conditions
Interventions
Intervention1: Dapagliflozin: Dapagliflozin 10mg once a daily will be given along with Standard Of Care treatment for 12 months
Control Intervention1: Standard Of Care Treatment: Maintenance therapy
Sponsors
DR MANISH RATHI
Eligibility
Inclusion criteria
Inclusion criteria: All newly diagnosed Lupus Nephritis with biopsy proven(Classes - III, IV, V, III +V, IV+V) are eligible if they are above 18 year of age
Exclusion criteria
Exclusion criteria: 1.Patient having pulmonary alveolar haemorrhage 2.Patient with neuropsychiatric SLE 3.Patient with rapidly progressive renal failure 4.Patient who are on hemodialysis 5.Patient with eGFR less than 25ml per min per 1.73m2 6.Patient with baseline creatinine more than 3mg per dl 7.Patient unwilling to give consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment Response as per KDIGO guidelines, Serum Creatinine , 24hr urine proteinTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of urinary tract infection in both Arms,Number of Lupus flare in both Arm, Number of SLE related complications & deaths in each Arms.Timepoint: Followed up after every monthly for 6 months & 3 monthly until 12 months. | — |
Countries
India
Contacts
Public ContactDR YOGESH E KHANDAGALE
PGIMER
Outcome results
None listed