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Strengthening Strategies for Knee Osteoarthritis: Eccentric vs. Isometric Exercise

Strengthening Strategies for Knee Osteoarthritis: A Randomized Trial of Eccentric vs. Isometric Exercise - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/080577
Enrollment
100
Registered
2025-02-14
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: Eccentric exercise + conventional care (ECC group): The ECC group will receive 15 sessions of eccentric knee flexor-extensor and hip extensor-abductor exercises along with 18 sessions o
recommended mobilization with movement, including patellar gliding for knee OA - 6-10 reps/1-3 sets
application of therapeutic pulsed ultrasound at 1-MHz/ 0.8 W/cm/ 5 minutes/ once a day (Use a 5cm2 diameter applicator) under the supervision of the physiotherapist. After that, during the 4th 18th
eccentric knee extensor exercise on a thigh extension machine
eccentric hip extensor exercise on a Roman chair set 30 relative to the floor
and eccentric hip abductor exercise using a cable machine in the gymnasium
weight will be distributed according to the participants tolerance level and conditions - 10 reps/1-3 sets. Finally, cool down for 5 minutes. Intervention2: Isometric exercise + conventional care (IS

Sponsors

Kazi Md Azman Hossain
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Individuals will be included in this trial if (1) ages 45 70 for both men and women, (2) the presence of knee OA for at least six months following American College of Rheumatology criteria, (3) able to walk without the use of any aids and able to flex the knee beyond 90 degrees, (4) anterior-posterior bilateral standing radiograph presents Kellgren and Lawrence Grade II/III knee OA, and (5) absence any unusual cardiac response during the six-minute walk test.

Exclusion criteria

Exclusion criteria: Individuals will be excluded if (1) knee surgery has been performed in the previous twelve months, (2) lumbar radiculopathy, vascular claudication, severe anterior-sided knee pain resulting from patella-femoral syndrome or chondromalacia, as well as further neurological, muscular, or joint conditions that could impair the function of the lower limbs, (3) visible malformation of the knee, either varus or valgus, (4) Received hyaluronic acid or corticosteroid injections within three months of study enrollment, (5) pregnancy, and (6) BMI over 30

Design outcomes

Primary

MeasureTime frame
Pain (Numeric Pain Rating Scale), Pressure Pain Threshold (Algometer), Muscle strength (Sphygmomanometer), Range of Motion (Goniometer)Timepoint: At baseline, after 6 weeks and 24 weeks

Secondary

MeasureTime frame
Functional ability (WOMAC), Walking ability (6MWT)Timepoint: 10 months

Countries

Bangladesh

Contacts

Public ContactAbid Hasan Khan

Jashore University of Science and Technology (JUST), Jashore

kmazman51@gmail.com01660140833

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026