Salivary biomarker comparison among healthy gingiva, periodontitis with and without habit of smoking

Comparison of salivary ph, alkaline phosphatase, lectate dehydrogenase, amylase, calcium, sodium and magnesium among healthy gingiva, periodontitis with and without smoking - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080543

Enrollment

Registered

2025-02-13

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Smokers with Periodontitis: The subjects will be asked to rinse thoroughly with distilled water before the collection of saliva. Five minutes after the oral rinse the subjects will be a

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age group between 18 60 years. 2. Minimum 15 natural teeth should be present in dental arch excluding 3rd molar. 3. The periodontally healthy individuals will be selected on the basis of probing depth of less than equal to 3mm, with no radiographic evidence of alveolar bone loss and attachment loss and no bleeding on probing. 4. Generalised periodontitis individuals who has consumed more than five cigarettes a day since past 5 years will be selected on the basis of probing depth of greater than equal to 5mm with a minimum of eight teeth, clinical attachment loss with or without bleeding on probing and having moderate bone loss on an ortho-pantomogram (OPG). 5. Generalised periodontitis individuals who has never smoke any cigarettes will be selected on the basis of probing depth of grater than equal to 5mm with a minimum of eight teeth, clinical attachment loss with or without bleeding on probing and having moderate bone loss on an ortho-pantomogram (OPG).

Exclusion criteria

Exclusion criteria: 1. Other form of tobacco users. 2. Smokers who have quite the habit of smoking in the last 6 months. 3. History of hospitalization or intake of medications in last 6 months. 4. Previous history of periodontal therapy in last 6 months.

Design outcomes

Primary

Measure	Time frame
Salivary Biomarkers- Salivary pH, alkaline phosphatase, lactate dehydrogenase, amylase, calcium, sodium and magnesiumTimepoint: Baseline, and 1 Month	—

Secondary

Measure	Time frame
Probing Depth, Plaque Index, Gingival Index, Clinical Attachment LevelTimepoint: Baseline and 1 Month	—

Countries

India

Contacts

Public ContactDr Krunal Parmar

Dharmsinh Desai University

pateldrvasu@yahoo.in8200210769

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026