Skip to content

A study to compare Suggamadex and Neostigmine in elderly patients undergoing general anaesthesia using Vecuronium

A Randomised study to compare Suggamadex Vs Neostigmine in Reversal of Vecuronium based Neuromuscular Block in Geriatric patients. - nil

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/080445
Enrollment
106
Registered
2025-02-12
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: SUGGAMADEX: At the end of the surgery(when the TOF monitor is at 2-3 twitches), Inj. Suggamadex is given immediately as a Reversal agent for Neuromuscular block.It is given through intr

Sponsors

Dr Kalieswaran Murugan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: INCLUSION CRITERIA 1)Patient with age greater than 60 years irrespective of sex of the patient. 2)Patient who are undergoing Elective Surgery in various OT under general anesthesia 3)Patients with ASA grade 1 and 2 4)Patients who have given written and informed consent

Exclusion criteria

Exclusion criteria: EXCLUSION CRITERIA 1)Patient refusal to give consent 2)Patient with any known or suspected neuromuscular disease 3) Anticipated difficult intubation 4)History suggestive of sensitivity to drugs used in the study 5)Personal or Family history of Malignant hyperthermia 6)Patient with known case of Chronic Kidney Disease 7)Patient with known case of Chronic Liver Disease

Design outcomes

Primary

MeasureTime frame
recovery time from administration of reversal to reach train of four ratio greater than or equal to 0.9Timepoint: 1 hr

Secondary

MeasureTime frame
Time to tracheal extubationTimepoint: 1.5 hrs;Time of shifting the patient from Operating Room to Post Operative Care UnitTimepoint: 2 hrs;Hemodynamic change ( Heart Rate , Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure , ECG rhythm ) after administration of the reversalTimepoint: baseline (2minutes before drug administration) & each minute(1 minute , 2 minutes, 3 minutes, etc )after drug administration till Train recovery time from administration of reversal to reach train of four ratio greater than or equal to 0.9 (1 hr(60 minutes))

Countries

India

Contacts

Public ContactDr Rajib Hazarika

Gauhati medical college and hospital

rajibhazarika8@gmail.com9864063140

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026