A study on how to lighten dark spots on gums using microneedling with and without topically applied niacinamide, compared to the traditional scalpel method

Gingival depigmentation using Microneedling technique with and without topical application of Niacinamide versus the conventional scalpel technique: A randomized controlled clinical trail - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080441

Enrollment

Registered

2025-02-12

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K068- Other specified disorders of gingiva and edentulous alveolar ridge

Interventions

Intervention1: Use of the Microneedling technique for reducing gingival pigmentation: To evaluate the effectiveness of the Microneedling (MN) technique with niacinamide, MN technique alone, and conven

Eligibility

Inclusion criteria

Inclusion criteria: Individuals with physiologic melanin pigmentation on the anterior portion of the upper and lower gingiva. Systemically healthy individuals. Individuals of 16-45 years of age from both genders.

Exclusion criteria

Exclusion criteria: Patients with habits of tobacco in any form, pan chewing etc. Pregnant or lactating women. Individuals with periodontal disease. Patients who had previous depigmentation procedures done. Patients who are allergic to niacinamide. Patients on drugs that cause gingival pigmentation like antimalarial, oral contraceptives, ketoconazole etc.

Design outcomes

Primary

Measure	Time frame
The effect of using the MN technique along with and without topical application of niacinamide compared to the effect of conventional scalpel technique in reducing pigmentation in hyperpigmented gingiva.Timepoint: 4 months	—

Secondary

Measure	Time frame
Whether microneedling technique with and without topical niacinamide shows better post operative healing as compared to conventional scalpel technique. Timepoint: 4 months;Whether microneedling technique with and without topical niacinamide shows less post operative pain as compared to conventional scalpel technique.Timepoint: 4 months	—

Countries

India

Contacts

Public ContactDr Abhijeet Shete

Tatyasaheb Kore Dental College and Research Center, New Pargaon

drabhijeetshete@gmail.com9325220496

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026