A study to compare 3 different drug combination for post operative analgesia for patients undergoing knee surgeries

A Randomized control Trail Comparing Post operative Analgesic Effect of Dexmeditomidine vs Nalbuphine as an Adjuvant with Ropivacaine in USG Guided Adductor Canal Block in Patients Undergoing Knee Surgeries - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080423

Enrollment

120

Registered

2025-02-12

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: ropivacaine with dexmeditomidine: ultrasound guided adductor canal nerve block with ropivacaine(0.5% 20ml) with dexmeditomidine(50mcg)and postoperative pain within the first 24 hours is

Eligibility

Inclusion criteria

Inclusion criteria: Age 18-65 ASA PS 1-2 All patients undergoing knee surgeries. Both sexes

Exclusion criteria

Exclusion criteria: Patient refusal Contraindications to regional nerve block: Cellulitis / infection at the local site Coagulopathy Allergy to local anaesthetic agents Patients with pre existing nerve injury.

Design outcomes

Primary

Measure	Time frame
Time to first rescue analgesia demand. If VAS score more than 3 Inj.paracetamol and if VAS 3-6 Inj. tramadol 100mg in 100ml NS. Timepoint: 1st hour,2nd hour,3rd hour,4th hour,5th hour,6th hour,12th hour,18th hour,24th hour	—

Secondary

Measure	Time frame
Requirement of total analgesic doses in first 24hours. VAS score for first 24hours Early ambulation based on TUG TEST. Timepoint: 1st hour,2nd hour,3rd hour,4th hour,5th hour,6th hour,12th hour,18th hour,24th hour	—

Countries

India

Contacts

Public ContactDr K Karthik

SRM Institute Of Science and Technology

karthikkrishnamoorthy1981@gmail.com9884360796

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026