Diaphragm Ultrasound in ARDS for evaluating the advantage of Theophylline and anti-oxidant

Diaphragm Ultrasound to evaluate therapeutic effect of theophylline and anti-oxidant in ARDS - A Randomized Controlled Study - DUTTAARDS

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080406

Enrollment

Registered

2025-02-12

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J80- Acute respiratory distress syndrome

Interventions

Intervention1: Theophylline and Vitamin-E: Patients with mild-moderate ARDS grouped into ‘Experimental groups’ will receive Theophylline 3-6 mg/kg oral and Vitamin-E 400 I.U/ day after informed consen

Eligibility

Inclusion criteria

Inclusion criteria: Clinical History and investigations that support diagnosis of mild-moderate ARDS

Exclusion criteria

Exclusion criteria: 1. Severe ARDS 2. MODS 3. Pregnancy 4. Severe traumatic brain injury 5. Phrenic nerve injury 6. Hepatic dysfunction 7. Abdominal Surgeries 8. Renal failure on RRT 9.Long term use of Steroids

Design outcomes

Primary

Measure	Time frame
To evaluate the effects of the combination of theophylline and antioxidants as adjunctive therapy with the standard treatment in the outcome of mild-moderate ARDS patients by serial ultrasound imaging of diaphragm.Timepoint: Day 1,2,3,4,5,6,7	—

Secondary

Measure	Time frame
Determine the length of ICU stayTimepoint: Day 1,2,3,4,5	—

Countries

India

Contacts

Public ContactDr M Akhilesh

Nizams Institute of Medical Sciences

akhil24.thewall@gmail.com7799548485

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026