Comparing Hyaluronidase and Dexamethasone Injections for reducing Pain, Swelling and inability to open mouth after Wisdom Tooth Surgery.

Evaluation of Hyaluronidase Vs Dexamethasone Submucosal Injections in Reducing Post Operative Sequalae after Disimpaction of Bilateral Impacted Mandibular Third Molar - A Split Mouth Study - NIL

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080399

Enrollment

Registered

2025-02-12

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Hyaluronidase: 1500 International Units 1ml , one time, Parenteral route-submucosal injection for one minute slowly. Control Intervention1: Dexamethasone: 1ml , one time, Parenteral rou

Eligibility

Inclusion criteria

Inclusion criteria: Age group 18-40 years Healthy and Non-Diabetic patients. Patients falling under physical status classification (American society of Anesthesiologists) ASA 1 and ASA 2 individuals Compliance with the study following voluntary participation. Patients with similar class of Bilateral Impacted Mandibular molar teeth (mesioangular, class-1,position A or B)

Exclusion criteria

Exclusion criteria: History of adverse effects to any drugs to be administered during the study period. Pregnant or lactating woman. Long-term use of drugs that affect systemic inflammatory response. Patients who are not willing to be involved in the study.

Design outcomes

Primary

Measure	Time frame
Post operative pain, mouth opening and swellingTimepoint: Pre operative day 1, post operative days 3rd, 7th ,14th day	—

Secondary

Measure	Time frame
No Secondary outcome measured .Any adverse events will be notedTimepoint: Pre operative day 1, post operative days 3rd, 7th ,14th day	—

Countries

India

Contacts

Public ContactEdara Samuel

Dr.Ntr university of health sciences

pscomf@gmail.com9392103703

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026