Effect of lung protective ventilation on brain pressure in patient with head injury.

Effect of low tidal volume ventilation on cerebral hemodynamics in Patients with severe traumatic brain injury

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080328

Enrollment

Registered

2025-02-11

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S062- Diffuse traumatic brain injury

Interventions

Intervention1: low tidal volume: The ventilatory strategy followed will be high tidal ventilation followed by low tidal ventilation in the same patient with an interval of 30 to 45 minutes. The ventil

Eligibility

Inclusion criteria

Inclusion criteria: Severe traumatic brain injury, Within 24 hours of injury, Receiving mechanical ventilation with a tidal volume of 10ml/kg of ideal body weight (IBW)

Exclusion criteria

Exclusion criteria: Patients with associated ocular injury, spinal cord injury, chest injury, history of aspiration, chronic cardiopulmonary disease, lung disease, obstructive sleep apnea, body mass index of more than or equal to 30 kg/m2, fraction of inspired oxygen requirement > 0.4

Design outcomes

Primary

Measure	Time frame
Change in optic nerve sheath diameter.Timepoint: 1 Hour	—

Secondary

Measure	Time frame
The secondary objective is to see the effect of low tidal volume ventilation regional cerebral oxygen saturation.Timepoint: 45-60 Minutes	—

Countries

India

Contacts

Public ContactAshish Bindra

AIIMS, NEW DELHI

dr_ashi2208@yahoo.com8826417127

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026