To compare divided dose vs one single dose of drug injected into the spinal area to evaluate haemodynamic stability of patients undergoing lower abdominal surgeries and lower limb surgeries

Comparison of fractionated dose versus bolus dose injection in spinal anaesthesia for patients undergoing lower abdominal and lower limb surgery A prospective randomise single-blind study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/02/080326

Enrollment

Registered

2025-02-11

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: 1- Obstetrics

Interventions

Intervention1: Fractionate dose injection of bupivacaine and buprenorphine.: Fractionated dose injection in spinal anaesthesia for patients undergoing lower abdominal surgeries and lower limb surgerie

Eligibility

Inclusion criteria

Inclusion criteria: 1.American society of anaesthesiologist (ASA) grade I - III 2.Age 18 - 40yrs 3.Scheduled for lower abdominal surgeries under spinal anaesthesia

Exclusion criteria

Exclusion criteria: 1.Patient Refusal 2.History of allergy to study drug 3. Post spinal surgeries 4.spinal deformities 5.skin sepsis in lumbar region. 6.Patients with pre-existing neurological disorders 7.Coagulopathy 8.Major hepatic,renal and cardiovascular malformation 9.Weight less than 60kg and more than 110kgs

Design outcomes

Primary

Measure	Time frame
To compare haemodynamic stability of both groups.Timepoint: 6 Hours	—

Secondary

Measure	Time frame
Assessing the time of onset and highest level of motor and sensory block.Timepoint: 6hours	—

Countries

India

Contacts

Public ContactAkalya Jayapal

Chettinad Hospital And Research Institute

ashokk_dr@yahoo.com9840498420

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026