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Effect of Eccentric Strengthening Exercise in patients with Knee Osteoarthritis

Effect of Eccentric Strengthening Exercise in Knee Osteoarthritis - NIL

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/080250
Enrollment
100
Registered
2025-02-10
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: Eccentric strengthening exercise + conventional care (experimental group): The experimental group will receive 15 sessions of eccentric knee flexion-extension and hip abduction strength
recommended mobilization with movement including patellar gliding for knee OA
application of therapeutic pulsed ultrasound under the supervision of the physiotherapist. After that, during the 4th – 18th sessions participants will perform: eccentric knee flexor exercise on prone
eccentric knee extensor exercise on thigh extension machine
and eccentric hip abductor exercise using a cable machine in gymnasium
weight will be distributed according to the participants’ tolerance level and conditions. Control Intervention1: Isometric strengthening exercise + conventional care (control group) : The control gro
application of therapeutic pulsed ultrasound under the supervision of the physiotherapist. After that during the 4th – 18th sessions participants will

Sponsors

Kazi Md Azman Hossain
Lead Sponsor
Jashore University of Science and Technology JUST
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Individuals will be included in this trial if (1) ages 45 – 70 for both men and women, (2) the presence of unilateral knee OA for at least six months following American College of Rheumatology criteria, (3) able to walk without the use of any aids and able to flex the knee beyond 90 degrees, (4) anterior-posterior bilateral standing radiograph presents Kellgren and Lawrence Grade II/III knee OA, and (5) absence any unusual cardiac response during the six-minute walk test.

Exclusion criteria

Exclusion criteria: Individuals will be excluded if (1) knee surgery has been performed in the previous twelve months, (2) lumbar radiculopathy, vascular claudication, severe anterior-sided knee pain resulting from patella-femoral syndrome or chondromalacia, as well as further neurological, muscular, or joint conditions that could impair the function of the lower limbs, (3) visible malformation of the knee, either varus or valgus, (4) Received hyaluronic acid or corticosteroid injections within three months of study enrollment, (5) pregnancy, and (6) BMI over 30.

Design outcomes

Primary

MeasureTime frame
Pain (Numeric Pain Rating Scale), Pressure Pain Threshold (Algometer), Muscle strength (Sphygmomanometer), Functional disability (WOMAC)Timepoint: 5 months

Secondary

MeasureTime frame
Range of Motion (Goniometer), Aerobic Capacity (6MWT), Depression severity (PHQ-9)Timepoint: 5 months

Countries

Bangladesh

Contacts

Public ContactDr. Tofajjal Hossain

Jashore University of Science and Technology (JUST), Jashore

mz.hossain@just.edu.bd01670962775

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026