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Impact of Combined Metformin Use and Aerobic Exercise on Metabolic and Inflammatory Markers in Type 2 Diabetes

Synergistic Effects of Metformin and Aerobic Exercises on Osteocalcin, Insulin, IL-6, Glucose Levels and BMI on Patients with Diabetes Mellitus Type 2 - NIL

Status
Unknown
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/080245
Enrollment
377
Registered
2025-02-10
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E08-E13- Diabetes mellitus

Interventions

Intervention1: Metformin: Metformin(orally) 500mg/BD (1000mg/day) 6 weeks Intervention2: Metformin + Aerobic exercises: Metformin(orally) 500mg/BD (1000mg/day) 6 weeks Aerobic exercises (30min/day) f

Sponsors

Muhammad Institute of Medical and Allied sciences Multan
Lead Sponsor
Komal Ammar Bukhari
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. 20-60 years 2. Patients with T2DM 3. Both genders

Exclusion criteria

Exclusion criteria: 1. Vascular neoplasia 2. Fibromyalgia 3. Radiculopathy 4. Neuropathy 5. Tumor 6. Joint fractures 7. Vestibular problems 8. Congenital disorders

Design outcomes

Primary

MeasureTime frame
Osteocalcin levels will be measured using serum concentration assays (ELISA). Insulin levels will be assessed through fasting insulin tests Interleukin-6 (IL-6) levels will be quantified via serum cytokine assays (ELISA). Blood Glucose levels (Random and fasting blood glucose level)will be monitored using fasting blood glucose tests Hemoglobin A1c (HbA1c) for long-term glycemic control. Body Mass Index (BMI) will be calculated using height and weight measurements. Diabetes self-management will be assessed using the Diabetes Self-Management Questionnaire (DSMQ) , while Quality of life will be evaluated using the Diabetes Quality of Life (DQoL) Timepoint: 6 weeks—

Secondary

MeasureTime frame
Lipid profile ( LDH,HDL,Triglycerides) Blood pressure VO2 max Physical fitness will be evaluated using the 6-minute walk test Timepoint: 6 weeks—

Countries

Pakistan

Contacts

Public ContactDr. Maliha Khalid Khan

Muhammad Nawaz Sharif University of Agriculture Multan

imran.ahmad@mnsuam.edu.pk03336120602

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026