Health Condition 1: A419- Sepsis, unspecified organism Health Condition 2: R57- Shock, not elsewhere classified
Conditions
Interventions
Intervention1: Indocyanine green test: ICG is reconstituted with the provided diluent to form solution of concentration 1 ml containing 5 mg of ICG . The dose given to the patient is calculated based
Sponsors
TMC Research Administrative Council
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1.Adults admitted to the ICU with refractory septic shock who are receiving methylene blue therapy 2.Consent from the LAR to participate in the study
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1.Known allergy to methylene blue or indocyanine green 2.Known G6PD deficiency or any hemolytic disorder 3.Pre existing cardiovascular disease 4.Previously recorded ejection fraction less than 40 percentage 5.Patients with survival expectancy less than 24 hours 6.Patients whose LAR refuse consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of methylene blue on splanchnic circulation in patients with refractory shockTimepoint: 1. Within 30 min of starting the methylene blue 2. 1 hour after starting the methylene blue | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU and hospital mortality, SOFA score, GI bleed incidence, Need for renal replacement therapy and RRT free daysTimepoint: At discharge from ICU and hospital | — |
Countries
India
Contacts
Public ContactDr A Koushik
Tata Memorial Centre
Outcome results
None listed