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Effect of laser as an adjunct for root canal disinfection in patients with dental caries with pulpal necrosis and apical periodontitis

Metagenomic Quantification of 16sRNA of the Total Microbial Load in Patients with Pulpal Necrosis and Apical Periodontitis following Low-Level Laser Therapy, Laser- Assisted Irrigation and Passive Ultrasonic Irrigation - A Double Blind Randomized Controlled Clinical Trial - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/080215
Enrollment
72
Registered
2025-02-10
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Low Level Laser Therapy: laser exposure will be carried out using a continuous mode with 10 Hz frequency, 980 nm wavelength, and max power 15 WCW. The tip was applied both at the buccal
displacement amplitude, approximately 30 mm
in accordance with the manufacturer’s instructions) for 60 sec. Control Intervention2: Laser activated irrigation: At the final step of irrigation, the irrigant will be activated with diode laser (980
in accordance with the manufacturer’s instructions) for 60 sec. The tip of the ultrasonic device will be introduced to 2 mm short of the working length and activated p

Sponsors

SRM Dental College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients in the age group of 18-45 years 2.Maxillary and mandibular premolars diagnosed with pulpal necrosis with apical periodontitis 3.Teeth with an endodontically preservable coronal tooth structure 4.Patients under ASA I category

Exclusion criteria

Exclusion criteria: 1.Patients who underwent antibiotic treatment within the previous 24 hours. 2.Teeth with probing depths indicating an endodontic-periodontal lesion 3.Previously endodontically treated teeth 4.Teeth with severely curved root canals 5.Pregnant and lactating patients 6.Immunocompromised patients 7.Patients in ASA- II, III, IV and V categories

Design outcomes

Primary

MeasureTime frame
Total Microbial Load ReductionTimepoint: Baseline

Secondary

MeasureTime frame
Reduction in painTimepoint: Baseline

Countries

India

Contacts

Public ContactDr H Srujana

SRM Institute of Science and Technology

mahalaxr@srmist.edu.in9381018598

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026