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COMPARISON OF TWO DRUGS NEBULIZATION IN REDUCING HEART RATE AND BLOOD PRESSURE RESPONSE TO PNEUMOPERITONIUM DURING SHORT DURATION GYNEACOLOGICAL LAPAROSCOPIC SURGERIES

COMPARISON OF LIGNOCAINE VS DEXMEDETOMIDINE NEBULIZATION IN ATTENUATING PRESSOR RESPONSE TO PNEUMOPERITONIUM DURING SHORT DURATION GYNEACOLOGICAL LAPAROSCOPIC SURGERIES -A DOUBLE BLIND RANDOMIZED COMPARATIVE STUDY

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/080198
Enrollment
66
Registered
2025-02-10
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: NEBULIZATION WITH 4% LIGNOCAINE OR DEXMEDITOMEDINE: Patient will be started on nebulization of either mentioned drugs for over 20 mins after noting baseline hemodynamic, for a duration

Sponsors

Dr SAINATH T
Lead Sponsor
Dr GAYATRI MISHRA
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. American society of anesthesiologists patient status (ASA PA) 1 and 2 2. Surgery duration less than 3 hours

Exclusion criteria

Exclusion criteria: 1. emergency cases 2. patients with decreased autonomic control such as uncontrolled diabetic patients 3. Anosmia, allergic rhinitis 4. patients with preoperative hypotension, bradycardia, dysrhythmia, severe cardiac diseases, complete heart block 5. patient with sinus bradycardia with HR lessthan 50/min, patient taking beta blockers, hepatic or renal dysfunction, obese patients with (BMI more than 30kg/sq meter) 6. patients with history of sleep apnea 7. Known allergy to either of the study drug will be excluded from the study.

Design outcomes

Primary

MeasureTime frame
To measure and compare the mean arterial pressure variation due to pneumoperitoneum between the two study groups.Timepoint: 15 months

Secondary

MeasureTime frame
1.To measure and compare the heart rate, blood presure variation due to pneumoperitoneum between the two study groups 2. To compare the intra operative opioid requirement in the two study groups. 3. To measure and compare recovery time in the two study groups. 4.To compare the post operative pain scores using VNRS score in the two groups.Timepoint: 15 months

Countries

India

Contacts

Public ContactDr GAYATRI MISHRA

Mahatma Gandhi medical College and research institute

drgayatrimishra@gmail.com9894354068

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026