Nebulization with Adrenaline and Hypertonic saline vs Hypertonic saline alone in Acute Bronchiolitis.

Study to evaluate the Efficacy and Safety of nebulization with Adrenaline and 3% Hypertonic saline vs nebulization with 3% Hypertonic saline alone in Acute Bronchiolitis: A Randomized Controlled Trial. - NIL

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2025/02/080142

Enrollment

132

Registered

2025-02-07

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J219- Acute bronchiolitis, unspecified

Interventions

Intervention1: ADRENALINE AND 3% HYPERTONIC SALINE: Nebulized inhalation of epinephrine and hypertonic 3% saline, administered at every 4 hours for 3 days and then modified as per patient’s need Cont

Eligibility

Inclusion criteria

Inclusion criteria: Admitted patient with a chronological age of 2 months to 24 months, a clinical diagnosis of Acute bronchiolitis and their initial Wang respiratory score will be 3 or higher will be enrolled in this study

Exclusion criteria

Exclusion criteria: Attendants not giving consent. Children with prior illness with wheezing. Children with prior use of bronchodilators. Premature infants ( Children with congenital heart disease. Children with chronic lung disease. Severe bronchiolitis (either wang CSS >9 or baseline oxygen saturation

Design outcomes

Primary

Measure	Time frame
1-To evaluate the efficacy of nebulization with adrenaline and 3% hypertonic saline vs nebulization with 3% hypertonic saline alone. 2-To evaluate the safety of nebulization with adrenaline and 3% hypertonic saline vs nebulization with 3% hypertonic saline alone. Timepoint: Evaluation Every 24 Hour	—

Secondary

Measure	Time frame
To evaluate the changes in clinical scoring after nebulization with adrenaline & 3% hypertonic saline vs nebulization with 3% hypertonic saline aloneTimepoint: Evaluation Every 24 Hour.;To evaluate the changes in average length of hospital stay after nebulization with adrenaline & 3% hypertonic saline vs nebulization with 3% hypertonic saline aloneTimepoint: Evaluation every 24 hour	—

Countries

India

Contacts

Public ContactDr Amit Shekharay

Narayan Medical College and Hospital

manikant7@yahoo.com9162095353

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026