Health Condition 1: H186- Keratoconus
Conditions
Interventions
Intervention1: NIL: NIL
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: a Either Sex b Age = 18 Yrs. c Sporadic (non-inherited) cases of KC (with or without their family member) d No corneal scarring e Patient willing to give consent for the study
Exclusion criteria
Exclusion criteria: a Patients under the age of 18 Yrs. b Cases of KC with previous corneal transplantation/post-LASIK Ectasia etc. c History of previous ocular disease, surgery, or trauma d Patient not willing to participate in the study e Patients not willing for investigations, tear fluids and blood sampling f Corneal scarring, ocular diseases such as glaucoma, uveitis, or ocular infections g History of systemic diseases such as diabetes, autoimmune disorders or cancer h Patients who are pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In this current study, we plan to undertake a multi-omics based integrative approach to achieve the following objectives: Comprehensive integrated sequencing, tear proteomics, candidate gene validation and de novo approach to identify altered targets, biomarkers, and clinically actionable novel variants in keratoconus Timepoint: 3-Years | — |
Secondary
| Measure | Time frame |
|---|---|
| NATimepoint: 0.00 | — |
Countries
India
Contacts
Public ContactDr Ramkishor Sah
Dr. R P Centre, All India Institute of Medical Sciences (AIIMS)
Outcome results
None listed