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A study to compare how well dexmedetomidine reduces the changes in blood pressure and heart rate when given intravenously in two different doses during administration of general anaesthesia with endotracheal tube.

A Prospective study to compare the efficacy to compare the efficacy of two different doses of intravenous Dexmedetomidine in attenuating the hemodynamic responses during laryngoscopy and endotracheal intubation. - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/080072
Enrollment
60
Registered
2025-02-07
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravenous infusion of Demedetomidine 1mcg/kg: Inj. Dexmedetomidine 1mcg/kg intravenously as an infusion in 100ml Normal Saline 30 minutes prior to induction of general anaesthesia. C

Sponsors

Smt. Bhikiben Kanjibhai Shah Medical Institute and Research Centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients willing to sign informed consent Male or female patients between 18 to 60 years of age Patients belonging to American Society of Anesthesiologists physical status I and II Patients posted for elective surgeries under general anaesthesia

Exclusion criteria

Exclusion criteria: Patients unwilling to participate in the study Patients with Body Mass Index more than 30 kg/m2 Patients with history of muscular disorder myositis or any local infection Patients with cardiovascular diseases arrhythmias heart blocks or taking beta blockers Patients with cerebrovascular, hepatic and renal diseases. Psychiatric patients. Patients with history of allergy to an a-2 adrenergic agonist Pregnancy & lactating women.

Design outcomes

Primary

MeasureTime frame
to check efficacy of dexmedetomidine for blunting hemodynamic resonse during laryngoscopy and intubation via intravenous route in two different dosesTimepoint: baseline every 15 minutes after administrating drug at induction at laryngoscopy at 3 mins at 5 mins at 7 mins—

Secondary

MeasureTime frame
to study sedation status post operativelyTimepoint: post operatively sedation status will be assessed every 30 minutes for 3 hours by RAMSAY sedation score—

Countries

India

Contacts

Public ContactDr Sara Mary Thomas

Smt. Bhikiben Kanjibhai Shah Medical Institute and Research Centre

sara.cinosh@gmail.com9646500158

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026