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Association of Salivary Catalase Activity and Oxidative Stress in Early Childhood Caries: A Biomarker for Caries Risk

Comparative Evaluation of Catalase Enzyme Production In Children With and Without Early Childhood Caries- A Randomized Control Trial - Nil

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/080045
Enrollment
100
Registered
2025-02-07
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K029- Dental caries, unspecified

Interventions

Intervention1: ECC group: Salivary catalase activity spectrometric assessment on DMFT index at baseline and 3 months Control Intervention1: Non ECC group: Salivary catalase activity, spectrometric ass

Sponsors

Saveetha Dental college and hospitals
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Children aged 3 6 years diagnosed with early childhood caries (ECC) based on the American Academy of Pediatric Dentistry (AAPD) criteria (ECC group). Caries-free children with no history of dental caries (Non-ECC group). Participants were recruited from paediatric dental clinics who were accompanied by parents or guardians who gave informed consent.

Exclusion criteria

Exclusion criteria: Children with underlying health conditions or medical issues. Children with special needs or disabilities. Children on medications affecting salivary composition. Children with any oral soft tissue lesions. Children who had received fluoride treatment in the last 2 weeks.

Design outcomes

Primary

MeasureTime frame
Primary outcome: Catalase enzyme activity in the saliva of children with and without ECC.at baseline and 3 monthsTimepoint: Primary outcome: Catalase enzyme activity in the saliva of children with and without ECC.at baseline and 3 months

Secondary

MeasureTime frame
DMFT index evaluation for caries experienceTimepoint: Immediate comparative assessment

Countries

India

Contacts

Public ContactDr Ramesh R

Saveetha university

rameshr.sdc@saveetha.com9895725236

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026