Health Condition 1: K650- Generalized (acute) peritonitis
Conditions
Interventions
Intervention1: L-Glutamine(L-Gln): Patients presenting with perforation peritonitis will be planned for operative procedure as in standardised surgical protocol as per diagnosis.
The intervention gro
Sponsors
Post Graduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 18 years to 80 years Perforation of stomach, small bowel and large bowel of any cause needing operative intervention Either sex (male or female) No previous history of nutritional formula supplementation Patients providing informed consent
Exclusion criteria
Exclusion criteria: Patients less than 18 years and more than 80 years Patients presenting with more than two organ failures Patients with localised perforation managed conservatively or by any interventional procedure Patients on mechanical ventilation for more than 72 hours Patients with chronic diseases (chronic liver disease, chronic kidney disease, chronic heart failure) Pregnant or lactating women Patients diagnosed with mental illness Patients diagnosed with immunodeficiency diseases or autoimmune diseases Patients with allergy to any nutritional formulas Patients with intolerance to feeding of immuno nutrition (vomiting or diarrhoea or abdominal distension or abdominal pain lasting for 12 to 24 hours even in minimal flow rate) Discontinuation of enteral nutrition for any reason in the first three days of administration Traumatic surgical patients (polytrauma)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory markers-total leukocyte count, differential leukocyte count, absolute neutrophil count, absolute lymphocyte count, C-reactive protein, procalcitonin, and albuminTimepoint: At Baseline, 24 hrs(Day 1), 72 hrs(Day 3) and 120 hrs(Day 5) | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative complications Readmission ratesTimepoint: 30 day morbidity,mortality | — |
Countries
India
Contacts
Public ContactKarthick M C
Post Graduate Institute of Medical Education and Research
Outcome results
None listed