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COMPARISON OF TWO DEVICES HIGH-FLOW NASAL CANNULA VERSUS BI- LEVEL NON-INVASIVE POSITIVE PRESSURE VENTILATION FOR INITIAL TREATMENT OF BREATHING DIFFICULTY IN ADULTS

EFFICACY OF HIGH-FLOW NASAL CANNULA VERSUS BI- LEVEL NON-INVASIVE POSITIVE PRESSURE VENTILATION FOR INITIAL MANAGEMENT OF ACUTE RESPIRATORY FAILURE IN ADULTS: A RANDOMIZED CONTROL STUDY - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/079983
Enrollment
100
Registered
2025-02-06
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J960- Acute respiratory failure

Interventions

Intervention1: high flow nasal cannula device: to provide high flow nasal oxygen in patients of acute respiratory failure and study rate of failure in 1st 48 hours. Control Intervention1: Comparing hi

Sponsors

NONE
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients > 18 years of age of either sex (both male and female) with respiratory failure fulfilling criteria PaO2/FiO2: 100-300 mmHg

Exclusion criteria

Exclusion criteria: Arterial blood pH Imminent respiratory arrest with need for urgent intubation Severe facial/nasal trauma hindering the use of either modality Upper airway tumors/ foreign body leading to significant obstruction Decrease consciousness (GCS Patients on domiciliary BiPAP therapy Prior tracheostomized patients Failure to secure patient/ family member/ legal guardian’s consent

Design outcomes

Primary

MeasureTime frame
TREATMENT FAILURE AT 48 HOURSTimepoint: TREATMENT FAILURE AT 48 HOURS—

Secondary

MeasureTime frame
DYSPNEA SCORE, COMFORT SCORE, COMPLICATIONS AND 28-DAY MORTALITYTimepoint: 2,6,12,24 AND 48 HOURS. AND 28 DAYS—

Countries

India

Contacts

Public ContactDR SAURABH TANEJA

INSTITUTE OF CRITICAL CARE MEDICINE, SIR GANGA RAM HOSPITAL

vinodksingh66@yahoo.co.in9810301011

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026