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Can Alkalinized Lignocaine Reduce Sore Throat and Coughing After Surgery? A Study on Patients Undergoing Kidney Stone Removal

Effect of alkalinised lignocaine for inflating reinforced endotracheal tube cuff on postoperative sorethroat and coughing in patients undergoing Percutaneous Nephrolithotomy in prone position - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/02/079948
Enrollment
136
Registered
2025-02-04
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N20-N23- Urolithiasis

Interventions

Intervention1: Endotracheal tube intracuff Alkalanized lignocaine: Cuff filled with air will be deflated and inflated with same amount of mixture (19 ml 2% lignocaine : 1 ml 8.4% sodium bicarbonate) t

Sponsors

Sanjay Gandhi Post Graduate Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA grade 1 and 2 2.Age between 18 to 65 years of either sex 3.Mallampatti classification 1 or 2

Exclusion criteria

Exclusion criteria: 1.ASA grade 3 and 4 2.Anticipated difficult intubation 3.More than two attempts of laryngoscopy 4.Failed extubation 5. Active upper respiratory tract infections 6. Bronchial asthma, COPD, chronic cough, previous laryngeal or tracheal surgery 7. Allergies to local anaesthetics 8. Impaired cognitive ability 9. Gastric tube insertion

Design outcomes

Primary

MeasureTime frame
To compare the incidence and severity of postoperative cough immediately after the extubation between the alkalinized lignocaine and air inflation of ETT cuff. Timepoint: To compare the incidence and severity of postoperative cough immediately after the extubation(baseline) between the alkalinized lignocaine and air inflation of ETT cuff.

Secondary

MeasureTime frame
1. To compare the incidence and severity of POST and hoarseness at 1 hour and 24 hour postoperatively. Timepoint: At 1 hour and 24 hour after extubation

Countries

India

Contacts

Public ContactPrateek Singh

Sanjay Gandhi Post Graduate Institute of Medical Sciences

prateeksiingh@gmail.com7007017131

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026