Health Condition 1: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Intervention1: Personalized Regimen: 1. 25 percent albumin infusion with monitoring of
2. Hrly - MAP, HR, Urine output, Respiratory rate,SpO2 ,Temperature
3. 3Hrly - POCUS, IVC Target less than 20 wit
Sponsors
Institute of Liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with cirrhosis and AKI with sepsis
Exclusion criteria
Exclusion criteria: 1. AKI- secondary to post renal causes such as nephrolithiasis 2. Patient already on maintenance hemodialysis/RRT 3. Patients with shock requiring vasopressors 4. Patient with history of structural heart disease and LVEF less than 50% 5. Patient with known COPD 6. Patient on Mechanical ventilation with P/F ratio less than 200 7. Patient with POCUS based features of volume overload[Presence of B lines ] 8. HCC - Beyond MILAN criteria 9. Patient in need of surgical intervention 10. Patient with history of adverse reaction to Albumin infusion 11. Pregnant or Lactating Women 12. Portal or hepatic vein thrombosis 13. Volume Overload with baseline IVC more than 20 14. Failure to provide informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients having resolution of AKI at 48hrs or 7days without the development of adverse eventsTimepoint: 48hrs or 7days | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative dose of albumin (in g/day) used in both arms at 48 hours and day 7Timepoint: 48 hours and day 7;Time to initiation of vasoconstrictors and resolution of AKITimepoint: day 7;Proportion of patients requiring invasive or non-invasive mechanical ventilation at 48 hours and at day7Timepoint: 48 hours and at day7;Proportion of patients developing cardiopulmonary complications in both groupsTimepoint: 7 days;28-day mortality of hospitalized patients with AKI in Cirrhosis.Timepoint: 28 days;Proportion of patients with AKI progression or requiring dialysis at 48 hours and day 7.Timepoint: 48 hours and day 7;SOFA and SIRS score changes at 48 hrs and 7 daysTimepoint: 48 hrs and 7 days | — |
Countries
India
Contacts
Public ContactDr Rakhi Maiwall
Institute of Liver and Biliary Sciences
Outcome results
None listed