Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: sugammadex: Sugammadex,a modified gamma-cyclodextrin, is a selective relaxant-binding agent ,specifically developed for rapid reversal of non depolarising neuromuscular blockade .
Contr
Sponsors
SRM medical college hospital and research centre
Eligibility
Inclusion criteria
Inclusion criteria: ASA PS GRADE I,II Patients scheduled for surgery under general anaesthesia requiring tracheal intubation
Exclusion criteria
Exclusion criteria: Anticipation of difficult airway Known or suspected history of neuromuscular disorders allergic to narcotics/muscle relaxants significant renal or liver dysfunction pregnant females
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time taken from the start of administration of suggamadex or neostigmine to recovery of TOF ratio to 0.9 will be recorded in patients undergoing rocuronium induced neuromuscular blockade.Timepoint: This will be checked at every 15 seconds for the first 3 minutes, every 30 seconds (3-5 minutes) and at every minute after 5 minutes of administration of reversal agent. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Clinical tests of postoperative neuromuscular recovery will be assessed by recording tof while patient does sustained headlift and sustained handgrip for 5 seconds post extubation 2)Patients will be monitored for side effects like cough, hypotension, bradycardia, nausea, vomiting, excess salivation post surgery.Timepoint: comparison of the efficacy between both the drugs can be demonstrated by detecting residual neuromuscular blockade post surgery and reduced risk of side effects | — |
Countries
India
Contacts
Public ContactMohammed Arshad N
SRM medical college hospital and research centre
Outcome results
None listed