To compare the action of dexmedetomidine drug given through the nostrils vs blood on changes in heart rate and blood pressure during keyhole surgeries in adult patients.

Comparison of effect of intravenous vs intranasal dexmedetomidine on stress response to pneumoperitoneum in adults undergoing laparoscopic surgery: a double blinded hospital based randomised clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/079737

Enrollment

Registered

2025-01-29

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: INTRANASAL DEXMEDETOMIDINE: After obtaining the approval of ethical committee, written informed consent will be taken from patients meeting the inclusion criteria after pre anaesthetic

Eligibility

Inclusion criteria

Inclusion criteria: 1) ASA physical status 1 and II 2) Patients undergoing laparoscopic surgeries under general anaesthesia 3) Provides consent

Exclusion criteria

Exclusion criteria: 1) Patient refusal or unable to give consent 2) ASA physical status III & above 3)Patients with nasal deformities. 4)Patients allergic to study drug.

Design outcomes

Secondary

Measure	Time frame
To determine the side effects of study drug if any.Timepoint: UPTO 6 HOURS POST OP.	—

Primary

Measure	Time frame
To study the effect of intravenous vs intranasal dexmedetomidine on stress response to pneumoperitoneum in laparoscopic surgeriesTimepoint: Baseline(Preop),5 mins before Pneumoperitoneum(T0),At the time of Pneumoperitoneum(TP),and then every 5mins thereafter[5mins (T5),10mins (T10),15mins (T15),20mins (T20),25mins (T25),30mins (T30)]	—

Countries

India

Contacts

Public ContactVARSHA B SHETTY

Jawaharlal Nehru Medical College, Belagavi

vandanagogate@gmail.com9844083030

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026