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To See The Effect of Oral Antihypertensive for The Attenuation of Haemodynamic Response to Laryngoscopy and Tracheal Intubation

Clinical Evaluation of Oral Melatonin and Oral Clonidine for The attenuation of Haemodynamic Response to Laryngoscopy and Tracheal Intubation - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/01/079672
Enrollment
60
Registered
2025-01-28
Start date
Unknown
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Oral Melatonin: T.Melatonin 9mg orally will be given 120min before induction of anaesthesia with sips of water Control Intervention1: Oral Clonidine: T.Clonidine 200mcg will be given or

Sponsors

Gandhi Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion Criteria 1)Age group between 18-60 years 2)Patients of both sex male and female. 3)ASA grade I & II. 4) Patient undergoing Surgery under General Anaesthesia.

Exclusion criteria

Exclusion criteria: Exclusion Criteria 1 Patient refusal. 2 Patients with ASA grade III, IV or higher. 3 Patient on anti hypertensive and hypoglycaemics. 4 Patient with asthmatic disease. 5 Patient already on melatonin or clonidine.

Design outcomes

Primary

MeasureTime frame
To evaluate the efficacy, haemodynamic stability in laryngoscopy and intubation following oral pre medication with melatonin and clonidine.Timepoint: 180min—

Secondary

MeasureTime frame
To assess effect on preoperative sedation.Timepoint: 180 min—

Countries

India

Contacts

Public ContactDr Rajkumar Ahirwal

Gandhi Medical College,Bhopal

brajeshkaushal3@gmail.com8839551736

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026