Clinical Evaluation of difference in the rate of tooth movement using TiO2 nanoparticles coated orthodontic wire and conventional orthodontic wire with the help of biomarkers

Clinical Evaluation of difference in the rate of retraction using TiO2 nanoparticles coated orthodontic wire and conventional orthodontic wire with the help of biomarkers- a split-mouth study - NIL

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/079665

Enrollment

Registered

2025-01-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: TiO2 coated archwire: Half portion of 19*25 rectangular archwire is coated with TiO2 nanoparticles by sol gel dip method. rate of tooth movement is compared with uncoated side by measur

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients requiring maxillary premolars extractions. 2.Good systemic health. 3.Not on Antibiotic therapy within last 6 months. 4.No use of antiinflammatory drug in a month preceding the study. 5.Healthy periodontium with probing depth less tha or equal to 3mm and no bone less radiographically.

Exclusion criteria

Exclusion criteria: 1.systemic diseases or syndromes. 2.Long term anti inflammatory medication 3.History of previous orthodontic treatment. 4.Parafunctional habits 5.Grossly decayed teeth. 6. Facial asymmetry and TMJ dysfunction. 7.Extracted or missing permanent teeth.

Design outcomes

Primary

Measure	Time frame
1. Level of IL-1 beta AND TNF-Alpha in GCF.Timepoint: 24 hours, 7th day and 21st day GCF samples during canine retraction period.	—

Secondary

Measure	Time frame
Rate of tooth movement in test & control sides.Timepoint: RATE OF CANINE MOVEMENT IN TEST AND CONTROL SIDES DURING RETRACTION PERIOD.	—

Countries

India

Contacts

Public ContactAparna A V

tpchaturvedident@bhu.ac.in9451570848

Outcome results