Health Condition 1: D496- Neoplasm of unspecified behavior of brain
Conditions
Interventions
Intervention1: Ketofol infusion for maintenance of anesthesia: Continuous infusion, given intravenously, from start of surgery to end of surgery, at the dose of 0.3 mL/kg/hour
Control Intervention1: P
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: ASA grade I & II patients, patients with supratentorial tumor size less than 5 cm, posted for elective craniotomy for tumor excision
Exclusion criteria
Exclusion criteria: Refusal of consent, patients who are expected to need postoperative elective ventilation having massive cerebral edema, midline shift, vascular or high-grade tumor, expected duration of anesthesia greater than eight hours, patients with preoperative GCS less than fifteen, altered sensorium or having aphasia, patients with BMI more than thirty five kg per meter square, pregnant females, patients having psychiatric illness or drug abuse, patients having aphasia, patients requiring post-operative ventilation, patients having history of allergic reactions to study drug, history of previous craniotomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time for emergenceTimepoint: One point assessment at the end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate & mean arterial pressure, Intra-operative brain bulge, Time for extubation, Time for recovery, SOMCT in the early postoperative period, Post-operative nausea & vomiting during the early recovery period, Complications of study drugs Timepoint: Intraoperative parameters will be recorded baseline, 5 minutes after intubation, 1 minute after pin insertion completion, 1 minute after skin incision, 1 minute after Dural opening, every 30 minutes intraoperatively, 1 minute after extubation | — |
Countries
India
Contacts
Public ContactBhavna
AIIMS, New Delhi
Outcome results
None listed