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Need for Perioperative steroid administration in patients undergoing Endoscopic transsphenoidal resection of pituitary adenoma

Perioperative steroid administration versus no steroid administration in patients with intact hypothalamic-pituitary axis undergoing Endoscopic transsphenoidal resection of pituitary adenoma: A randomized control study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/01/079501
Enrollment
72
Registered
2025-01-27
Start date
Unknown
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E349- Endocrine disorder, unspecified

Interventions

Intervention1: NOSTEROID (Placebo/ Inj 0.9%/Normal Saline): Those not receiving perioperative hydrocortisone replacement. The NOSTEROID will receive no hydrocortisone before, during, or after surgery

Sponsors

Department of Neurosurgery AIIMS Jodhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Pituitary adenoma requiring endoscopic transsphenoidal surgical resection 2 Intact HPA axis

Exclusion criteria

Exclusion criteria: 1 Patients with preoperative adrenal insufficiency or Cushings Disease 2 Patients on steroids for other systemic illnesses 3 Patients on drugs that could affect the HPA axis 4 Patients refusing consent for surgery/study. 5 Pregnancy

Design outcomes

Primary

MeasureTime frame
1. To compare the perioperative serum cortisol levels and 2. The incidence of adrenal insufficiency postoperatively after endoscopic trans nasal resection in patients of pituitary adenoma with an intact hypothalamic-pituitary-adrenal (HPA) axis during the 1st three postoperative days for the primary outcomeTimepoint: Preoperative period Post operative day 1 Post operative day 2—

Secondary

MeasureTime frame
The incidence of adrenal insufficiency postoperatively after endoscopic transnasal resection in patients of pituitary adenoma with an intact hypothalamic-pituitary-adrenal (HPA) axis during 1st 3 months postoperatively for secondary outcomeTimepoint: 3 months after endoscopic transnasal resection in patients of pituitary adenoma—

Countries

India

Contacts

Public ContactJaskaran Singh Gosal

AIIMS Jodhpur

jhsgosal_87@hotmail.com6283475891

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026