Azithromycin versus Doxycycline for treatment of Scrub Typhus in children

Comparison of oral Azithromycin versus oral Doxycycline in children with Scrub Typhus A randomized controlled study - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/079498

Enrollment

194

Registered

2025-01-27

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A753- Typhus fever due to Rickettsia tsutsugamushi

Interventions

Intervention1: Azithromycin: Oral Azithromycin 10mg/kg once daily for 5 days with a maximum dose of 500mg/day Control Intervention1: Doxycycline: Oral Doxycycline 4.4 mg/kg/day for 5 days with a maxim

Eligibility

Inclusion criteria

Inclusion criteria: 1.All children with clinical and microbiologically proven scrub typhus of all paediatric age group admitted in paediatric ward.

Exclusion criteria

Exclusion criteria: 1.children of parents who refused to give consent 2.Children with known allergy to either of these two drugs 3.Children who received anti microbials like Azithromycin or Doxycycline in proceeding 2 weeks

Design outcomes

Primary

Measure	Time frame
To study the time taken for fever defervescence in two groups one using azithromycin and the other using doxycyclineTimepoint: Temperature of the patient is checked every 4 hours	—

Secondary

Measure	Time frame
NilTimepoint: Nil	—

Countries

India

Contacts

Public ContactSUNKARA KRISHNA AISWARYA

Sri Manakula Vinayagar Medical College and Hospital, Puducherry

drhemanthbhk@gmail.com9655738271

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026