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Compartive Study of Nebulized Ropivacaine and Nebulized Ropivacaine with dexmedetomidine

A RANDOMIZED STUDY TO COMPARE THE EFFECT OF NEBULIZED ROPIVACAINE AND NEBULIZED ROPIVACAINE WITH DEXMEDETOMIDINE ON ATTENUATING HEMODYNAMIC RESPONSE TO INTUBATION IN PATIENTS UNDERGOING SURGERY UNDER GENERAL ANAESTHESIA - Nil

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/01/079428
Enrollment
80
Registered
2025-01-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K35- Acute appendicitis Health Condition 2: H661- Chronic tubotympanic suppurative otitis media Health Condition 3: N25- Disorders resulting from impairedrenal tubular function Health Condition 4: G89-G99- Other disorders of the nervous system Health Condition 5: M97- Periprosthetic fracture around internal prosthetic joint

Interventions

Intervention1: Ropivacaine: Nebulize They Patient With 0.5% Ropivacaine See They Hemodynamic Response they total duration of this study is 1.5 years. Control Intervention1: Ropivacaine AND Dexemedetom

Sponsors

Ashu Agarwal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient giving consent for study 2. Weight 40-70 kg 3. ASA grade 1 & 2 4. Patients undergoing surgery under general anaesthesia 5. All lab investigations within normal range

Exclusion criteria

Exclusion criteria: 1. Patient with a history of sore throat or upper respiratory tract infection 2. Hemodynamically unstable patients 3. Emergency patients 4. Patients with a history of allergy to local anesthetics 5. Patents with a history of allergy to dexmedetomidine 6. Patients with a history of cardiac, liver, or renal disorders. 7. Patient with a difficult airway where the anticipated duration of laryngoscopy exceeded 15 seconds. 8. ASA 3 and 4

Design outcomes

Primary

MeasureTime frame
.To access and compare they hemodynamic changes HR , SBP, DBP,MAP, Spo2 and ETco2 in both the groupsTimepoint: Before Nebulization ,After Nebulization, Before Intubation ,After Intubation, 5 minute after intubation ,at skin closure ,after extubation, 5 minutes after extubation—

Secondary

MeasureTime frame
1. To compare the cough response at extubation in both the groups. 2. The incidence rate of postoperative sore throat. In both the groups. Timepoint: sore throat at time of extubation, 2 hour, 4 hour,6hour,12 hour,24 hour cought response at time of extubation—

Countries

India

Contacts

Public ContactDr. Pratibha Rathore

Jhalawar Medical College Jhalawar

PRATIBHA.RATHORE3@GMAIL.COM9414446473

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026