a clinical study comparing the effectiveness of dexamethasone and magnesium sulphate versus placebo in preventing post-operative sore throat (POST) following endotracheal intubation.

Comparative placebo controlled study of dexamethasone and Magnesium sulphate in preventing post operative sore throat Following endotracheal intubation - Nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/079384

Enrollment

Registered

2025-01-24

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nebulisation: Pre Operative nebulisation for prevention of postoperative sore throat following endotracheal intubation Control Intervention1: nebulised with 5ml of normal saline.: Group

Eligibility

Inclusion criteria

Inclusion criteria: ASA I & II Modified Mallampatti Score 1-2.

Exclusion criteria

Exclusion criteria: 1.Patients who needed more than two attempts at endotracheal intubation and use of bougie and styllete 2. Patients with history of sore throat 3. Long term anti-inflammatory analgesic medications 4. Patients who have undergone insertion of devices which stimulate oral cavity, larynx, pharynx like nasogastric tube 5. Obese, diabetic, pregnant patients

Design outcomes

Primary

Measure	Time frame
To compare the effect of Dexamethasone versus Magnesium sulphate against placebo in preventing POST following endotracheal intubationTimepoint: at the time of start of surgery, 4 hours, 8 hours and 24 hours	—

Secondary

Measure	Time frame
To Compare the frequency and severity of post operative sore throat among the patients in each groupTimepoint: Patients will be assessed postoperatively at 0 hour, 4hr, 8hr 24th hour	—

Countries

India

Contacts

Public ContactDr Balkaran Sher Singh

Sri Gur Ram Das Institute of Medical Sciences and Research, Mehta Road, Vallah, Amritsar

gitzgitz@gmail.com9872981079

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026