Health Condition 1: M160- Bilateral primary osteoarthritis of hip Health Condition 2: M170- Bilateral primary osteoarthritis of knee Health Condition 3: M171- Unilateral primary osteoarthritisof knee
Conditions
Interventions
Intervention1: inj. dexmedatomedine 10 mcg
intracthecally with hyperbaric
bupivacaine: inj. dexmedatomedine 10 mcg
intrathecally as an additive to inj. bupivcaine hyperbaric to compare the hemodynamic
Sponsors
Smt. Bhikiben Kanjibhai Shah Medical Institute and research Centre
Eligibility
Inclusion criteria
Inclusion criteria: Patients willing to sign the informed written consent. Patients of ASA Grade I and II of either gender Under Spinal anaesthesia for elective pelvic and lower limb surgeries Aged 20 - 60 years. No known history of allergy, sensitivity to local anaesthetics of the amide group and other drugs used for this study.
Exclusion criteria
Exclusion criteria: Patient refusal. Patient not NIL by mouth. History of seizure disorder. Known allergy to trial drugs. Patients with neurological disorders and neuropathies or receiving medications known to influence neuromuscular junction. ASA III, IV, V Patients. Patient with prior pre-existing Comorbidities (Heart diseases, Respiratory disease, Kidney diseases, known fetal abnormalities) Pregnant females Failed spinal anesthesia converted to general anesthesia Any contraindication to Spinal Anaesthesia (local site infection, spine deformity, clotting abnormalities. Patients fulfilling above inclusion criteria are taken for study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| to Compare efficacy of dexmedatomedine and nalbuphine in blunting hemodynamic response and post operative analesgia in patient recieving Spinal anaesthesia in lower limb orthopedic surgeriesTimepoint: to Compare efficacy of dexmedatomedine and nalbuphine in blunting hemodynamic response and post operative analesgia in patient recieving Spinal anaesthesia in lower limb orthopedic surgeries Baseline 0 min 2 mins 5 mins 10 mins 20 mins 30 mins 45 mins 60 mins 90 mins 120 mins 150 mins 180 mins | — |
Secondary
| Measure | Time frame |
|---|---|
| to compare duration of post operative analgesia in group dexmedatomedine & group nalbuphineTimepoint: time at which rescue analgesia was given Vas Score at induction At 4 hours 6 hours 8 hours Or anytime between when Vas Score More then 4 | — |
Countries
India
Contacts
Public ContactDr Nilesh Shah
Smt. Bhikiben Kanjibhai Shah Medical Institute and research Centre
Outcome results
None listed