Three groups of participants will be given PHENYLEPHRINE 75mcgs,PHENYLEPHRINE 100mcgs and NS along with oxytocin as an intervention and best hemodynamic balance outcome will be observed .

A randomised comparative study on the effect of concomitant administration of various doses of intravenous phenylephrine with oxytocin for prevention of oxytocin-induced hypotension following caesarian section under spinal anesthesia. - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/079273

Enrollment

Registered

2025-01-23

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: phenylephrine , oxytocin: phenylephrine 75 mcgs I.V followed by oxytocin 3U I.V bolus over 10-15 mins. Control Intervention1: phenylephrine , oxytocin: phenylephrine 100 mcgs I.V. follo

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiology (ASA) grade I and II,Singleton full term pregnant patients posted for caesarean section, Hemodynamically stable patients with all routine investigations within the normal limits and without any other co morbidities,Patients who give informed written consent and are willing to be a part of the study.

Exclusion criteria

Exclusion criteria: unwilling female patients female patients above ASA3 female patient with any contraindication for neuraxial blockade.

Design outcomes

Primary

Measure	Time frame
To study the effect of concomitant administration of various doses of phenylephrine with oxytocin for prevention of oxytocin-induced hypotension following caesarian section under spinal anesthesiaTimepoint: baseline vitals every two minutes for first 10 minutes later every ten minutes till 70 minutes of procedure.	—

Secondary

Measure	Time frame
To evaluate Rescue vasopressor requirement To observe the magnitude of hemodynamic changes To study the incidence of side effects To study the effect of phenylephrine co ?administration on intraoperative blood lossTimepoint: baseline vitals every two minutes for first 10 minutes later every ten minutes till 70 minutes of procedure.	—

Countries

India

Contacts

Public ContactDR Bhavini Shah

DR D. Y. PATIL MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTRE , PIMPRI ,PUNE

drbhavinishah71@gmail.com9850829994

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026