One-Year Follow-Up Study on Periapical Healing After Single-Visit Root Canal Treatment Using Two Different Sealants

Periapical healing outcome of two different sealants in single visit RCT: 1 year follow - up study - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/079237

Enrollment

180

Registered

2025-01-22

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis

Interventions

Intervention1: Bioceramic sealer: Single visit root canal treatment using SafeEndo BioActive RCS Root Canal Sealant, 12 months follow - up Control Intervention1: Zinc Oxide Eugenol: Single visit root

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age between 18 â?? 70 years 2. Anteriors, premolars and molars 3. Uncomplicated non vital teeth with sinus tract , intraoral and extraoral swelling. 4. Asymptomatic non vital teeth with presence of periapical lesion

Exclusion criteria

Exclusion criteria: 1. Patient not willing for recall visits 2. Patients who cannot keep mouth open for long duration (TMJ disorders) 3. Cases with continuous flow of pus through the canal during Root Canal Treatment (Weeping canal). 4. Calcified, severely curved canals 5. Periodontally compromised teeth

Design outcomes

Primary

Measure	Time frame
Radiographic evaluation of healing of periapical lesionTimepoint: Radiographic evaluation of healing of periapical lesion after 1 year. Clinical evaluation of pain intensity 1st day, 2nd day and 7th day after completion of single visit root canal treatment	—

Secondary

Measure	Time frame
Assessment of pain after single visit root canal treatmentTimepoint: 1st day, 2nd day, 7 days after single visit root canal treatment	—

Countries

India

Contacts

Public ContactDr I Anand Sherwood

CSI COLLEGE OF DENTAL SCIENCES AND RESEARCH

anand.sherwood@gmail.com9443805150

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026