To find the difference between two drugs given by erector spinae block, which decreases pain after total laparoscopic hysterectomy surgery.

Comparison of Analgesic Efficacy of Dexamethasone and Dexmedetomidine as an Adjuvant to 0.375 percent Ropivacaine in Lower Thoracic Erector Spinae Plane Block for Total Laparoscopic Hysterectomy: A Prospective, Randomised, Double blind Study - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/079207

Enrollment

Registered

2025-01-22

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group A - Bilateral erector spinal plane block using injection ropivacaine 0.375% (20 ml)+ injection dexmedetomidine 0.5 mcg/kg (1ml), total 21 ml is given: Patients receives bilateral

Eligibility

Inclusion criteria

Inclusion criteria: Patients belonging to ASA PS class I and II. Patients undergoing Total laparoscopic hysterectomy of duration 1.5-2 hours in operation theatre with haemoglobin at least 9 gm/dl. Patients free from any associated acute or chronic systemic illness.

Exclusion criteria

Exclusion criteria: Uncooperative patients. Patients with chronic pain or on long term analgesics. Any known hypersensitivity or contraindication to ropivacaine. Local pathology at the site of injection or disability limiting the performance of block (deformity of spine). Patients receiving beta blockers or cardiac drugs . History of convulsions, allergy to drugs used , bleeding disorder, severe neurological deficits, thyroid disorder. Patient with a history of respiratory, cardiac, hepatic, or renal disease ( necessitating classification in ASA class III or above. Patients having a history of significant neurological, psychiatric, or neuromuscular disorder. Patients with deranged PT-INR .

Design outcomes

Primary

Measure	Time frame
To assess and compare postoperative time to first tramadol request .Timepoint: Baseline	—

Secondary

Measure	Time frame
To assess and compare : Visual analogue scale (VAS) score at rest and movement. Total amount of tramadol consumption in first 48 hours postoperatively. Onsets of sensory block. Duration of sensory block. Intraoperative fentanyl consumption. Haemodynamic parameters (HR,SBP,DBP,MBP). Sedation score. Any side effects ( nausea, vomiting, bradycardia, hypotension, respiratory depression).Timepoint: VAS score 1-10 Time in hours.	—

Measure

Time frame

To assess and compare : Visual analogue scale (VAS) score at rest and movement. Total amount of tramadol consumption in first 48 hours postoperatively. Onsets of sensory block. Duration of sensory block. Intraoperative fentanyl consumption. Haemodynamic parameters (HR,SBP,DBP,MBP). Sedation score. Any side effects ( nausea, vomiting, bradycardia, hypotension, respiratory depression).Timepoint: VAS score 1-10 Time in hours.

—

Countries

India

Contacts

Public ContactDr Beena Thada

JLN MEDICAL COLLEGE, AJMER, RAJASTHAN

drbeenaverma@gmail.com9352260425

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026