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Utility of rapid tests in HIV patients with involvement of brain

Impact of point of care tests on mortality in HIV patients with suspected Central Nervous system infection: a diagnostic randomised controlled trial from India - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/01/079206
Enrollment
198
Registered
2025-01-22
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A00-B99- Certain infectious and parasitic diseases

Interventions

Intervention1: Rapid tests: Urinary GeneXpert, serum cryptococcal antigen, urine pneumococcal polysaccharide antigen: Rapid tests: Urinary GeneXpert, serum cryptococcal antigen, urine pneumococcal pol

Sponsors

ICMR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: HIV patients with a first episode of suspected CNS infection

Exclusion criteria

Exclusion criteria: those patients who have an established microbiological diagnosis for CNS infection at presentation, suspected relapse of HIV related CNS infection, pregnancy or lactation, malaria, scrub typhus, leptospirosis, dengue

Design outcomes

Primary

MeasureTime frame
2-week mortalityTimepoint: 2-week mortality—

Secondary

MeasureTime frame
10-week mortality Time to appropriate tests and initiation of appropriate treatmentTimepoint: 10-week mortality Time to appropriate tests and initiation of appropriate treatment—

Countries

India

Contacts

Public ContactDr Nitin Gupta

Kasturba Medical College, Manipal

nitin.gupta@manipal.edu9868996079

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026