Time to awaken from anaesthesia (emergence time) following target-controlled (automatically by machine) vs manual controlled (by anaesthesiologist) infusion of propofol in patients undergoing endoscopic trans-sphenoidal (nasal approach) pituitary surgery: A Prospective, Randomized, Controlled study

Emergence time following target-controlled versus manual controlled propofol infusion in patients undergoing endoscopic trans-sphenoidal pituitary surgery: A Prospective, Randomized, Controlled study - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/079197

Enrollment

Registered

2025-01-22

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D3A8- Other benign neuroendocrine tumors

Interventions

Intervention1: Target controlled infusion: Propofol will be administered by Target controlled infusion (TCI) pump in the intervention group. Total duration- 18months Control Intervention1: Manual cont

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective endoscopic trans-sphenoidal pituitary tumour surgery, ASA physical Grade I & II

Exclusion criteria

Exclusion criteria: Refusal for consent, Emergency Surgery, Giant pituitary tumor more than 4cm, Tumors with major cavernous sinus infiltration and ICA encasement, Altered sensorium, Body Mass Index more than 35, Obstructive sleep apnoea, Psychiatric or psychological disorder, Anticipated difficult airway, History of any intracranial surgery in the past, Patients with Alcohol or substance abuse, Pregnant or lactating patient will be excluded from the study

Design outcomes

Primary

Measure	Time frame
Time to respond to verbal commands following cessation of anaesthetic drug infusion.Timepoint: From nasal packing to tracheal extubation.	—

Secondary

Measure	Time frame
Hemodynamics variability Total consumption of propofol & fentanyl Time to tracheal extubation Aldretes scores.Timepoint: Hemodynamics variability at baselines & every 15 minutes intraoperatively. Total consumption of propofol & fentanyl intraoperatively. Time to tracheal extubation at the end of surgery. Aldretes scores at 5 min after tracheal extubation.	—

Countries

India

Contacts

Public ContactDr Rajendra Singh Chouhan

All India Institute of Medical Sciences, New Delhi

drrajendrasinghchouhan@gmail.com9999069041

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026