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To compare preoperative nebulisation with Fentanyl or Dexmedetomidine or Magnesium Sulphate in blunting hemodynamic response to Laryngoscopy and Tracheal intubation in 171 participants chosen randomly.

A randomised comparative study of pre-op nebulization with Fentanyl, Dexmedetomidine or Magnesium Sulphate for blunting haemodynamic response to Laryngoscopy and Tracheal intubation - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/01/079170
Enrollment
171
Registered
2025-01-21
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: PRE OPERATIVE NEBULIZATION WITH FENTANYL,DEXMEDITOMIDINE AND MAGNESIUM SULPHATE FOR BLUNTING HEMOADYNAMIC RESPONSE QITH LARYNGOSCOPIC AND TRACHEAL INTUBATION.: NEBULIZATION WITH FENTANY

Sponsors

Dr Subashini KJ
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients who are willing to participate in the study and giving valid consent 2. Patients with asa grade 1 and 2 in routine cases 3. Patients with mpc grade 1 and 2 4. Elective surgeries

Exclusion criteria

Exclusion criteria: 1.Patients who have uncontrolled diabetis mellitus or uncontrolled hypertension 2.Patients with coagulopathies or on anticoagulation medications 3.Patients who is having known hypersensitivity to study drugs 4.Patients with mpc 3 and 4, video laryngoscope guided or awake fiberoptic guided intubation

Design outcomes

Primary

MeasureTime frame
To compare the efficacy of nebulized drugs.Timepoint: Baseline, after 1 min , 2 min , 3 min , 5 min , 10 min , 15 min , 20 min, 25 min, 30 min, 1 hour, 2 hours.

Secondary

MeasureTime frame
1. To assess the onset of attenuation response caused by laryngoscopy & intubation. 2. To assess the duration of attenuation response caused by laryngoscopy & intubation. 3. To observe & report any adverse reactions.Timepoint: Baseline, after 1 min , 2 min , 3 min , 5 min , 10 min , 15 min , 20 min, 25 min, 30 min, 1 hour, 2 hours.

Countries

India

Contacts

Public ContactDr Sukriti Atram

Grant Government Medical college and Sir JJ Hospital.

sukritiatram@gmail.com9004083034

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026