Health Condition 1: G309- Alzheimers disease, unspecified
Conditions
Interventions
Intervention1: Brahmi Nei: Brahmi Nei (8g) will be administered BD for 120 days based on the literature (Siddha vaithiya thirattu). Brahmi Nei (BN) is an Indian Sidddha formulation that has been used
Sponsors
Pratiksha Trust
SASTRA Deemed University
Eligibility
Inclusion criteria
Inclusion criteria: Written informed consent will be obtained from the from the subjects legal guardian and through audio visualization Patients within the age group of 55-80 years both male and female patients Individuals with an MMSE score of 11-20 and CDR score of 1 to 2 are eligible for the study Hypo-metabolic changes observed through PET imaging Hypertension less than 180 mm Hg of systolic pressure
Exclusion criteria
Exclusion criteria: Individuals with uncontrolled hypertension chronic renal disease hepatic disease and lung disease recurrent stroke Drug alcohol and substance abuse Patients already on other anti-dementic drugs and vascular drugs including statin therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cogition assesment using MMSE score, Clinical Dementia Rating Sum of Boxes and MoCA to assess the cognitive function level of AD subjects. Hypometabolic changes in AD patients brain to confirm the pathologyTimepoint: Day 0 Questionaire and 18 FDG PET DAY 45 Questionaire DAY 120 Questionaire and 18 FDG PET | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of Tau, BDNF markers in serum to determine the tau pathology and neurogenesisTimepoint: DAY 0 blood based biomarker ELISA DAY 45 Blood based biomarker ELISA Day 120 Blood based biomarker ELISA | — |
Countries
India
Contacts
Public ContactUMA MAHESWARI KRISHNAN
SASTRA Deemed University
Outcome results
None listed