Health Condition 1: K760- Fatty (change of) liver, not elsewhere classified Health Condition 2: E08-E13- Diabetes mellitus Health Condition 3: I51- Complications and ill-defined descriptions of heart disease
Conditions
Interventions
Intervention1: Millet Diet: Traditional breakfast millet recipes (roti/dosa/khichidi) for 3 months
Intervention2: Dietary Intervention: Millet diet-induced changes in Gut microbiota and biomarkers in
Sponsors
Department of Science and Technology
Eligibility
Inclusion criteria
Inclusion criteria: Group 1: Healthy volunteers -Normal (without type II diabetes mellitus (TY2DM), Cardiovascular Disease (CVD)/hypertension, Non-alcoholic fatty liver disease (NAFLD) /hyperlipidemia), Volunteers with following conditions: Group 2: type II diabetes mellitus (TY2DM)/prediabetes, Group 3: Cardiovascular Disease (CVD)/hypertension, Group 4: Non-alcoholic fatty liver disease (NAFLD) /hyperlipidemia) will be included in this study. The participants who are on medications for the above conditions will also be included.
Exclusion criteria
Exclusion criteria: People with severe illnesses, People already on a millet diet, Those with gastrointestinal symptoms and/or gastrointestinal diseases, Pregnant or lactating females and Those who have recently (past month) used antibiotics will be excluded from this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All participants will be subjected to analysis of changes in following biomarkers in blood sample analysis before and after millet intake- Diabetic/ prediabetic markers (Fasting Blood Sugar) CVD biomarkers (complete lipid profile, adiponectin, C-Reactive Protein, Angiotensin Converting Enzyme activity) Hepatic functions (Aspartate aminotransferase, Alanine transaminase, Alkaline phosphatase, Albumin, Bilirubin, Total protein, Gamma glutamyl transferase) Analysis of the gut microflora by 16S rRNA sequencing of stool samples before and after the millet intakeTimepoint: First and last day of the 3 months period of millet diet. | — |
Secondary
| Measure | Time frame |
|---|---|
| Beneficial effects of millets on the gut microbiome as evidenced by increase in gut microflora. Identification of newer disease management strategies to improve patient health outcome via dietary changes.Timepoint: First and last day of the 3 months period of millet diet. | — |
Countries
India
Contacts
Public ContactDr Priya S
CSIR National Institute for Interdisciplinary Science and Technology
Outcome results
None listed