Comparative Assessment of Antimicrobial Property and Bond Strength of Orthodontic Adhesive Containing Chitosan and Silver Nanoparticles: A Randomized Controlled Study

An Evaluation and Comparison of Microbial Colonisation and Bond Failure of Brackets Bonded with Orthodontic Adhesive Modified with Chitosan and Silver Nanoparticles: A Randomized Controlled Study - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/079111

Enrollment

Registered

2025-01-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K089- Disorder of teeth and supporting structures, unspecified

Interventions

Intervention1: Orthodontic adhesive modified with chitosan nanoparticles: 4 gm of adhesive (3M Unitek Transbond XT, Monrovia, CA, USA) will be incorporated with chitosan nanoparticles (100 mg) to achi

Eligibility

Inclusion criteria

Inclusion criteria: Patients who give consent for the study. Patients with mild crowding requiring fixed orthodontic treatment. Patients with good oral hygiene and healthy periodontium, OHI-S index score in the range of good to fair.

Exclusion criteria

Exclusion criteria: Patients who do not give consent for the study Patients with moderate to severe crowding Patients with compromised periodontium Systemic illnesses like uncontrolled diabetes mellitus, AIDS or any other immunocompromised conditions Patients on medications that causes gingival hyperplasia or antibiotics Missing teeth in the anterior region (15-25) in the upper arch Patients with localized gum disease

Design outcomes

Primary

Measure	Time frame
Evaluate and compare of antimicrobial properties of orthodontic adhesive modified with chitosan nanoparticles, silver nanoparticles and conventional orthodontic adhesiveTimepoint: Plaque sample will be collected around the brackets after 28th day (after 4 weeks) from the date of bonding	—

Secondary

Measure	Time frame
Evaluate & compare bond failure or debond rate of the brackets bonded with orthodontic adhesive modified with chitosan nanoparticles & silver nanoparticles & conventional orthodontic adhesiveTimepoint: Bond failure will be recorded upto 6 months from the date of bonding	—

Countries

India

Contacts

Public ContactDR ISHA SOMVANSHI

Manubhai Patel Dental College and Hospital, Vadodara

padmaja2216@yahoo.co.in9033975429

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026