Comparision of precautionary dose of intravenous bolus versus infusion dose of phnylephrine for prevention of spinal anaesthesia induced hypotension in elective cesarean section

Comparison of prophylactic intravenous bolus versus infusion of phenylephrine for preventing spinal anesthesia-induced hypotension in elective cesarean sections - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/079107

Enrollment

Registered

2025-01-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Spinal Anaesthesia: The Spinal Anaesthesia will be given after confirming free flow of CSF 0.5% heavy bupivacaine 2.4ml will be given . Control Intervention1: phenylephrine: Group A: Co

Eligibility

Inclusion criteria

Inclusion criteria: All the patients who are undergoing cesarean section or the patients falling under American Society of Anesthesiology (ASA) Grade II

Exclusion criteria

Exclusion criteria: 1. Contraindications to regional anesthesia such as anatomic disorders of spine, shock, local site infections, peripheral neuropathy. 2. Patients with the history of hypertension or pregnancy induced hypertension. 3.Patients with hypersensitivity to study drugs . 4.Patients with coagulation disorders and bleeding disorders. 5.Patients with cardiovascular or cerebrovascular disorders 6. Patients with fetal abnormality

Design outcomes

Primary

Measure	Time frame
to assess the effect of prophylactic doses of intravenous bolus versus infusion of phenylephrine for prevention of spinal induced hypotension in elective cesarean section. Timepoint: Continuous intraoperative, vitals will be recorded every 2min interval for first 10min and then at 5 min interval till the end of surgery. outcome will also be assessed in post anaesthetic care unit (PACU) at 15min interval.	—

Measure

Time frame

to assess the effect of prophylactic doses of intravenous bolus versus infusion of phenylephrine for prevention of spinal induced hypotension in elective cesarean section. Timepoint: Continuous intraoperative, vitals will be recorded every 2min interval for first 10min and then at 5 min interval till the end of surgery. outcome will also be assessed in post anaesthetic care unit (PACU) at 15min interval.

—

Secondary

Measure	Time frame
To assess intaoperative complications related to study drug. To calculate apgar scoreat 1 and 5 minute respectively.Timepoint: Throughout during the surgery and APGAR score will be assessed immidiatly and after 5 minutes of birth	—

Countries

India

Contacts

Public ContactDr Sakshi

Sri Gur Ram Das Institute of Medical Sciences and Research, Mehta Road, Vallah, Amritsar

sgrdanaesthesia@gmail.com9815632909

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026