To compare orthograde versus retrograde root canal filling technique during endodontic microsurgery in anterior teeth

Comparison of Two Root End Filling Techniques during Endodontic Microsurgery of Permanent Anterior Teeth: A Parallel Double Blind Randomized Clinical Trial - Endodontic Microsurgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/079057

Enrollment

Registered

2025-01-20

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis Health Condition 2: K041- Necrosis of pulp Health Condition 3: K046- Periapical abscess with sinus Health Condition 4: K047- Periapical abscess without sinus

Interventions

Intervention1: Orthograde MTA Appproach: Two visit Nonsurgical Root canal therapy will be performed with calcium silicate based cements placed at the root apex in second visit followed by backfilling

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients aged 18–60 years 2.Non-vital anterior teeth with single canal 3.Patients with Symptomatic Apical Periodontitis and Persistent apical periodontitis after NSET scheduled for periapical surgery with large (greater than 5mm) periapical lesion 4.Adequate access to apical third of the root

Exclusion criteria

Exclusion criteria: 1.Patients with systemic conditions affecting healing (e.g., diabetes) 2.Teeth with vertical root fractures 3.Apico-marginal defect 4.Patients with inadequate oral hygiene or periodontal health 5.Pregnant or lactating women

Design outcomes

Primary

Measure	Time frame
1. To evaluate the clinical and radiographic outcome of orthograde placement of root-end filling material followed by root end resection during endodontic microsurgery in permanent anterior teeth. 2. To evaluate the clinical and radiographic outcome of conventional retrograde placement of root-end filling material following root end resection and preparation during endodontic microsurgery in permanent anterior teeth. 3. To compare the aboveTimepoint: 6 months and 1 year	—

Measure

Time frame

1. To evaluate the clinical and radiographic outcome of orthograde placement of root-end filling material followed by root end resection during endodontic microsurgery in permanent anterior teeth. 2. To evaluate the clinical and radiographic outcome of conventional retrograde placement of root-end filling material following root end resection and preparation during endodontic microsurgery in permanent anterior teeth. 3. To compare the aboveTimepoint: 6 months and 1 year

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Secondary

Measure	Time frame
To evaluate the postoperative pain, swelling, analgesics needed, and patient reported quality of life (OHRQoL) for orthograde placement of root-end filling material followed by root end resection during endodontic microsurgery in permanent anterior teeth. 2. To evaluate the postoperative pain, swelling, analgesics needed, and patient reported quality of life (OHRQoL) for conventional retrograde placement of root-end filling material following root end resection and preparation during endodontic microsurgery in permanent anterior teeth. 3. To compare the aboveTimepoint: 1 week	—

Measure

Time frame

To evaluate the postoperative pain, swelling, analgesics needed, and patient reported quality of life (OHRQoL) for orthograde placement of root-end filling material followed by root end resection during endodontic microsurgery in permanent anterior teeth. 2. To evaluate the postoperative pain, swelling, analgesics needed, and patient reported quality of life (OHRQoL) for conventional retrograde placement of root-end filling material following root end resection and preparation during endodontic microsurgery in permanent anterior teeth. 3. To compare the aboveTimepoint: 1 week

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Countries

India

Contacts

Public ContactDr Sidhartha Sharma

Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi

sid.aiims@gmail.com9582542655

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026