Effect of preoperative vitamin C supplementation on postoperative functional status in patients with pulmonary hypertension due to valvular heart disease undergoing valve surgery

Effect of preoperative vitamin C supplementation on postoperative 6-minute walk distance in patients with pulmonary hypertension due to valvular heart disease undergoing valve surgery a randomized control trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/079015

Enrollment

144

Registered

2025-01-20

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I05-I09- Chronic rheumatic heart diseases

Interventions

Intervention1: TABLET VITAMIN C: Patients given Tab. Vitamin C 500mg per oral twice daily after food for 4 weeks Control Intervention1: PLACEBO: Patient receives Tab. Placebo twice daily for 4 weeks

Eligibility

Inclusion criteria

Inclusion criteria: Patients between 18 years and 80 years with pulmonary artery pressure with mean pulmonary artery pressure of more than 20mmHg measured by right heart catheterisation or right ventricular systolic pressure of more than 40mmHg with right atrial pressure measured with echocardiography with valvular heart disease planned for valve replacement surgeries

Exclusion criteria

Exclusion criteria: Pregnancy, Poorly controlled Diabetes mellitus, inherited blood disorders (Thalassemia, G6PD deficiency, Emergency surgeries and presence of RVOT obstruction

Design outcomes

Primary

Measure	Time frame
Assess the effect of preoperative oral vitamin c supplementation of post operative 6 minute walk distanceTimepoint: baseline and 7th postoperative day	—

Secondary

Measure	Time frame
Postoperative vasoactive scoreTimepoint: ON postoperative day 1;Postoperative pulmonary artery pressureTimepoint: At postoperative day 7 ;Duration of ICU stay & Hospital stayTimepoint: At the time of discharge;Postoperative cumulative blood lossTimepoint: Postoperative day 2	—

Countries

India

Contacts

Public ContactAjay Kumar Jha

JAWAHARLAL INSTITUE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH

jd1227@jipmer.ac.in9868477642

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026