Optimizing Respiratory Health in COPD Patients: The Role of Pre-Operative Ketamine (Nebulized vs. IV) in Laparoscopic Surgery

Comparison of pre-operative nebulization with ketamine versus intravenous ketamine on respiratory parameters in COPD patients undergoing laparoscopic abdominal surgery: a randomized control trial - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/079005

Enrollment

Registered

2025-01-20

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: IV KETAMINE: This will be the Primary group, to whom 0.4mg/kg iv ketamine (total volume 5ml) bolus + 0.4mg/kg infusion (total volume 100ml) &amp

nebulized saline will be administered Control Intervention1: NEBULIZED KETAMINE: This will be the Test Group, to whom nebulised ketamine (0.8mg/kg) & iv saline (5ml) bolus + infusion (100ml) will be a

Eligibility

Inclusion criteria

Inclusion criteria: Patients with COPD undergoing laproscopic abdominal surgery under GA ( with et/i-gel) Age: 18-70 yrs Physical status : asa ii,iii Laproscopic abdominal surgery under GA lasting upto 2 hrs Patient willing to provide informed consent

Exclusion criteria

Exclusion criteria: Administration of preoperative iv steroid therapy Patients who have previously undergone any airway surgery Patients with allergy to study drug Patients with known cardiac disease

Design outcomes

Primary

Measure	Time frame
to compare the effectiveness of pre-operative ketamine nebulisation versus iv ketamine on changes in peak expiratory flow rate (PEFR) in COPD patients undergoing laparoscopic abdominal surgery.Timepoint: 30minuites of intervention	—

Secondary

Measure	Time frame
1)To compare the forced expiratory volume in 1(FEV1) second measured pre and post intervention 2)Assessment of post intubation bronchospasm . 3)Assessment of side effects of ketamine : salivation, lacrimation, hallucination etc.Timepoint: 30 minuites post intervention	—

Countries

India

Contacts

Public ContactLALHLIMPUII FANAI

AIIMS,JODHPUR

docbpali@gmail.com9588089378

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026