Health Condition 1: C539- Malignant neoplasm of cervix uteri, unspecified
Conditions
Interventions
Intervention1: Extended field radiotherapy: Para aortic nodal volume will be added to the pelvic nodal volume and PTV tumor in Pelvic node positive cervical cancer which will receive 45Gy/25#/5weeks.
Sponsors
Department of Radiotherapy
Eligibility
Inclusion criteria
Inclusion criteria: 1. ECOG score of 0-2. 2. Patients with pelvic node metastasis (FIGO 2018 Stage IIIc1). 3.Pelvic lymph node metastasis (pathologic) diagnosed on CT scan/ MRI with highest pelvic node level 1 cm below the aortic bifurcation. 4. Previously untreated, biopsy proven cervical squamous cell carcinoma/ adeno-squamous cell carcinoma. 5. Suitable for concurrent chemoradiation with platinum based chemotherapy 6. Patient’s willingness to give informed consent for the treatment and regular follow up after completion of the treatment throughout the follow up period.
Exclusion criteria
Exclusion criteria: 1. Patients with para-aortic nodal disease (IIIC2), Stage IVA or Stage IVB disease . 2. Patients with horseshoe kidney. 3. Synchronous malignancy or previous history of malignancy. 4. Presence of uncontrolled or severe comorbidities. 5. Deranged renal function tests. 6. History of pelvic surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assess the quality of life in both RT arms after chemoradiation followed by brachytherapy.Timepoint: Baseline and 3months after completion of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Acute normal tissue response between the two arms.Timepoint: 1.Acute normal tissue reaction during the treatment and at 3 months after completion of treatment. ;Early treatment outcome after completion of RT in both arms.Timepoint: At 3 months after completion of treatment. | — |
Countries
India
Contacts
Public ContactSwapnil
Post Graduate Institute of Medical Education and Research
Outcome results
None listed