A study to compare the healing of large bony lesion due to dead tooth/teeth, treated either with removal of dead tooth and placing it back after removing the infection from the root canal or doing surgery of that tooth/teeth or only root canal treatment.

Healing outcome in nonsurgical root canal treatment versus periapical surgery versus Intentional replantation for management of large periapical lesion of Endodontic origin. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/01/078981

Enrollment

Registered

2025-01-20

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K049- Other and unspecified diseases ofpulp and periapical tissues

Interventions

Intervention1: Intentional Replantation: Delibrate extraction of teeth for better visualization of the diseased part and placing it back in the socket which is of the recognized treatment protocol. Th

Eligibility

Inclusion criteria

Inclusion criteria: Radiographically diagnosed with large periapical lesion more than 10mm associated with maxillary anterior teeth. Minimal marginal bone height of 2-3 mm. Acceptable periodontal status (probing depth less than 4mm).

Exclusion criteria

Exclusion criteria: Patients with systemic conditions which could compromise the healing. Cysts of non-odontogenic origin. Apico-marginal defect. Developmental anomaly of a tooth (palate gingival groove, dilaceration, PCO etc Cervical & External root resorption. Non restorable and teeth with vertical root fractures. Patients not willing to participate in the study.

Design outcomes

Primary

Measure	Time frame
To evaluate the clinical and CBCT outcome of maxillary anterior large periapical lesion of endodontic origin. a) Treated with intentional replantation with periapical curettage. b) Treated with periapical surgery. c) Treated with nonsurgical root canal treatment.Timepoint: Patients evaluated at baseline; after treatment for 1 week; 1 month and followed up for 6 months and 1 year	—

Secondary

Measure	Time frame
To identify the prognostic factors affecting the outcome of large periapical lesion treated with intentional replantation. 2.To evaluate and compare the patient oral health related quality of life after intentional replantation, periapical surgery and nonsurgical root canal treatmentTimepoint: 2 years	—

Countries

India

Contacts

Public ContactVineeta Nikhil

Subharti Dental College and Hospital/Swami Vivekanand Subharti University

tannusingh136@gmail.com9818963433

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026